The Super Bowl is the biggest advertising event of the year, with the biggest brands in the world flexing their advertising muscles (and budgets). A new entrant to the Super Bowl in 2024 was Pfizer, and they're back again this year with an ad that has blown the socks off the Pharma category. Their big game ad "<a href="https://www.youtube.com/watch?v=wNLhMZuA00c">Knock Out</a>", scored 4.4 stars in System1 testing, also making it one of the best ads overall. I speak with Pfizer CMO, Susan Rienow about what it takes to create such a successful ad in the most competitive environment.Timestamps00:00 - Intro 01:20 - Susan’s successful career so far 03:19 - What Pfizer does and their mission 04:21 - The Covid vaccine rollout 06:29 - The role of insights for making business decisions 07:36 - Dealing with the complexities of different audiences 10:12 - Managing the impact of fair balance in advertising 14:51 - The role of Pfizer’s advertising 17:04 - Why have Pfizer gone all in with a Super Bowl ad 20:12 - The Pfizer Super Bowl ad in 2025 25:20 - What role does testing play for creating an effective ad 33:31 - The role of testing giving confidence to the board 37:39 - How tiny changes can make such a big difference 39:15 - How to evaluate the impact of a Super Bowl ad 41:22 - What makes a great CMO 46:40 - Advice Susan would give to young marketers

How Pfizer made the highest scoring Pharma ad of all time - Susan Rienow